Cholecystokinin-8 vs TFF3
Head-to-head comparison of Cholecystokinin-8 (Cholecystokinin (sulfated C-terminal octapeptide, CCK-8)) and TFF3 (Trefoil Factor 3 (intestinal trefoil factor)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Cholecystokinin-8 | TFF3 |
|---|---|---|
| Category | Endocrine Peptides | Gastrointestinal |
| Full Name | Cholecystokinin (sulfated C-terminal octapeptide, CCK-8) | Trefoil Factor 3 (intestinal trefoil factor) |
| Molecular Weight | 1143.2 Da | 6370 Da |
| Half-Life | 1-2 min | unknown; likely short in circulation |
| Amino Acids | DY(SO3H)MGWMDF-NH2 | 59 |
| Typical Dose | physiologic low-picomolar-nanomolar range|research-dependent | research-only; model-dependent microgram to milligram ranges |
| Route | endogenous secretion|research IV/SC | Oral/Intrarectal |
| Purity | ≥98% | ≥98% |
| Studies Count | 97 | 70 |
| Research Status | Endogenous | Pre-clinical |
Cholecystokinin-8 Benefits
- ✓gallbladder contraction
- ✓pancreatic enzyme release
- ✓satiety signaling
TFF3 Benefits
- ✓epithelial-restitution
- ✓mucus-support
- ✓wound-healing
- ✓barrier-stability
Cholecystokinin-8 Dosing
physiologic secretion|research-dependent
TFF3 Dosing
preclinical dosing varies widely by model|local or systemic administration|repeated dosing for inflammatory injury studies
Cholecystokinin-8 Side Effects
- ⚠abdominal cramping
- ⚠nausea
- ⚠biliary contraction
TFF3 Side Effects
- ⚠limited human dosing data
- ⚠protein stability issues
- ⚠potential immunogenicity with exogenous use
Research Overview
Cholecystokinin-8
CCK-8 is a canonical gut hormone fragment with extensive documentation in digestive physiology and appetite control. Sulfation of the tyrosine residue is important for high-affinity receptor activity.
TFF3
TFF3 is a well-established mucosal repair factor in the literature, especially in the context of intestinal injury and inflammation. Experimental studies support a role in accelerating restitution and protecting the epithelial surface in gut disease models.
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