TFF3 vs Motilin
Head-to-head comparison of TFF3 (Trefoil Factor 3 (intestinal trefoil factor)) and Motilin (Motilin) — benefits, dosing, side effects, research data, and where to buy.
| Property | TFF3 | Motilin |
|---|---|---|
| Category | Gastrointestinal | Gastrointestinal |
| Full Name | Trefoil Factor 3 (intestinal trefoil factor) | Motilin |
| Molecular Weight | 6370 Da | ~2.7 kDa |
| Half-Life | unknown; likely short in circulation | ~20 min |
| Amino Acids | 59 | 22 |
| Typical Dose | research-only; model-dependent microgram to milligram ranges | No standard approved dose; experimental use only |
| Route | Oral/Intrarectal | IV|SC |
| Purity | ≥98% | ≥98% |
| Studies Count | 70 | 81 |
| Research Status | Pre-clinical | Endogenous |
TFF3 Benefits
- ✓epithelial-restitution
- ✓mucus-support
- ✓wound-healing
- ✓barrier-stability
Motilin Benefits
- ✓migrating motor complex support
- ✓gastric emptying
- ✓small-bowel clearance
TFF3 Dosing
preclinical dosing varies widely by model|local or systemic administration|repeated dosing for inflammatory injury studies
Motilin Dosing
0.1–1 mg (experimental)|IV/SC
TFF3 Side Effects
- ⚠limited human dosing data
- ⚠protein stability issues
- ⚠potential immunogenicity with exogenous use
Motilin Side Effects
- ⚠cramping
- ⚠nausea
Research Overview
TFF3
TFF3 is a well-established mucosal repair factor in the literature, especially in the context of intestinal injury and inflammation. Experimental studies support a role in accelerating restitution and protecting the epithelial surface in gut disease models.
Motilin
Motilin is a 22-amino-acid peptide released from the upper small intestine and is one of the classic physiologic prokinetic signals. It is a real peptide target for GI motility research, though not commonly used as a standard drug.
Ready to buy?
Find both peptides from our verified, lab-tested vendors with purity certificates and third-party testing.