Motilin vs Secretin
Head-to-head comparison of Motilin (Motilin) and Secretin (Human Secretin) — benefits, dosing, side effects, research data, and where to buy.
| Property | Motilin | Secretin |
|---|---|---|
| Category | Gastrointestinal | Gastrointestinal |
| Full Name | Motilin | Human Secretin |
| Molecular Weight | ~2.7 kDa | 3055.4 Da |
| Half-Life | ~20 min | 5-7 minutes |
| Amino Acids | 22 | 27 |
| Typical Dose | No standard approved dose; experimental use only | 0.2 mcg/kg IV |
| Route | IV|SC | Intravenous |
| Purity | ≥98% | ≥98% |
| Studies Count | 81 | 800 |
| Research Status | Endogenous | Clinical |
Motilin Benefits
- ✓migrating motor complex support
- ✓gastric emptying
- ✓small-bowel clearance
Secretin Benefits
- ✓stimulates-pancreatic-secretion
- ✓supports-bicarbonate-release
- ✓aids-duodenal-pH-control
- ✓helps-digestive-coordination
Motilin Dosing
0.1–1 mg (experimental)|IV/SC
Secretin Dosing
0.2 mcg/kg IV diagnostic dose|research infusion protocols|short bolus administration
Motilin Side Effects
- ⚠cramping
- ⚠nausea
Secretin Side Effects
- ⚠flushing
- ⚠nausea
- ⚠abdominal-cramping
Research Overview
Motilin
Motilin is a 22-amino-acid peptide released from the upper small intestine and is one of the classic physiologic prokinetic signals. It is a real peptide target for GI motility research, though not commonly used as a standard drug.
Secretin
Secretin is a classic GI hormone with extensive physiology literature and established diagnostic use. It remains important for studying pancreatic secretory function, biliary responses, and duodenal feedback.
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