Secretin vs Glucagon-like peptide-2
Head-to-head comparison of Secretin (Human Secretin) and Glucagon-like peptide-2 (Glucagon-like peptide-2) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Secretin | Glucagon-like peptide-2 |
|---|---|---|
| Category | Gastrointestinal | Gastrointestinal |
| Full Name | Human Secretin | Glucagon-like peptide-2 |
| Molecular Weight | 3055.4 Da | ~3.7 kDa |
| Half-Life | 5-7 minutes | ~7 min |
| Amino Acids | 27 | 33 |
| Typical Dose | 0.2 mcg/kg IV | Research-only dosing varies; native peptide is not routinely used clinically |
| Route | Intravenous | SC|IV |
| Purity | ≥98% | ≥98% |
| Studies Count | 800 | 90 |
| Research Status | Clinical | Endogenous |
Secretin Benefits
- ✓stimulates-pancreatic-secretion
- ✓supports-bicarbonate-release
- ✓aids-duodenal-pH-control
- ✓helps-digestive-coordination
Glucagon-like peptide-2 Benefits
- ✓mucosal trophic support
- ✓intestinal barrier repair
- ✓nutrient absorption support
Secretin Dosing
0.2 mcg/kg IV diagnostic dose|research infusion protocols|short bolus administration
Glucagon-like peptide-2 Dosing
0.5–2 mg/day (research)|SC/IV
Secretin Side Effects
- ⚠flushing
- ⚠nausea
- ⚠abdominal-cramping
Glucagon-like peptide-2 Side Effects
- ⚠nausea
- ⚠abdominal fullness
Research Overview
Secretin
Secretin is a classic GI hormone with extensive physiology literature and established diagnostic use. It remains important for studying pancreatic secretory function, biliary responses, and duodenal feedback.
Glucagon-like peptide-2
Native GLP-2 is a key enteric growth factor with rapid degradation by DPP-4. Its therapeutic value is best known through GLP-2 analog development, but the native peptide itself is a real GI-relevant hormone.
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