Secretin vs TFF3
Head-to-head comparison of Secretin (Human Secretin) and TFF3 (Trefoil Factor 3 (intestinal trefoil factor)) — benefits, dosing, side effects, research data, and where to buy.
| Property | Secretin | TFF3 |
|---|---|---|
| Category | Gastrointestinal | Gastrointestinal |
| Full Name | Human Secretin | Trefoil Factor 3 (intestinal trefoil factor) |
| Molecular Weight | 3055.4 Da | 6370 Da |
| Half-Life | 5-7 minutes | unknown; likely short in circulation |
| Amino Acids | 27 | 59 |
| Typical Dose | 0.2 mcg/kg IV | research-only; model-dependent microgram to milligram ranges |
| Route | Intravenous | Oral/Intrarectal |
| Purity | ≥98% | ≥98% |
| Studies Count | 800 | 70 |
| Research Status | Clinical | Pre-clinical |
Secretin Benefits
- ✓stimulates-pancreatic-secretion
- ✓supports-bicarbonate-release
- ✓aids-duodenal-pH-control
- ✓helps-digestive-coordination
TFF3 Benefits
- ✓epithelial-restitution
- ✓mucus-support
- ✓wound-healing
- ✓barrier-stability
Secretin Dosing
0.2 mcg/kg IV diagnostic dose|research infusion protocols|short bolus administration
TFF3 Dosing
preclinical dosing varies widely by model|local or systemic administration|repeated dosing for inflammatory injury studies
Secretin Side Effects
- ⚠flushing
- ⚠nausea
- ⚠abdominal-cramping
TFF3 Side Effects
- ⚠limited human dosing data
- ⚠protein stability issues
- ⚠potential immunogenicity with exogenous use
Research Overview
Secretin
Secretin is a classic GI hormone with extensive physiology literature and established diagnostic use. It remains important for studying pancreatic secretory function, biliary responses, and duodenal feedback.
TFF3
TFF3 is a well-established mucosal repair factor in the literature, especially in the context of intestinal injury and inflammation. Experimental studies support a role in accelerating restitution and protecting the epithelial surface in gut disease models.
Ready to buy?
Find both peptides from our verified, lab-tested vendors with purity certificates and third-party testing.