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GastrointestinalPre-clinical

TFF3

Trefoil Factor 3 (intestinal trefoil factor)

59 Amino Acids · MW: 6370 Da

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Amino Acids

59

Molecular Weight

6370 Da

Half-life

unknown; likely short in circulation

Research Score

4.1

Studies

70

Storage

Store lyophilized at -20°C, reconstituted at 2-8°C

What is TFF3?

Trefoil factor 3 is a small secreted peptide involved in epithelial restitution, mucus layer support, and mucosal healing. It is expressed in the intestine and has been studied in models of colitis, epithelial injury, and barrier dysfunction.

Key Benefits & Mechanisms

epithelial-restitution

mucus-support

wound-healing

barrier-stability

Research Summary

TFF3 is a well-established mucosal repair factor in the literature, especially in the context of intestinal injury and inflammation. Experimental studies support a role in accelerating restitution and protecting the epithelial surface in gut disease models.

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