Plecanatide
Plecanatide
16 Amino Acids · MW: Approx. 1620 Da
Amino Acids
16
Molecular Weight
Approx. 1620 Da
Half-life
Local intestinal action; systemic half-life not clinically meaningful
Research Score
5.0
Studies
350
Storage
Store lyophilized at -20°C, reconstituted at 2-8°C
What is Plecanatide?
A synthetic 16-amino-acid peptide and GC-C agonist related to uroguanylin. It is used to treat chronic idiopathic constipation and IBS-C by promoting intestinal secretion and softer stools.
Key Benefits & Mechanisms
improves-stool-frequency
supports-fluid-secretion
may-reduce-constipation
local-gut-action
Research Summary
Clinical trials show plecanatide improves constipation outcomes with a generally favorable tolerability profile. Like linaclotide, it acts locally in the intestinal lumen via GC-C signaling rather than systemic hormone effects.
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