Home/Database/Larazotide
GastrointestinalClinical

Larazotide

Larazotide acetate (AT-1001)

8 Amino Acids · MW: N/A

Ask AI About This

Amino Acids

8

Molecular Weight

N/A

Half-life

short; designed for local gut action

Research Score

4.3

Studies

40

Storage

Store lyophilized at -20°C, reconstituted at 2-8°C

What is Larazotide?

Larazotide acetate is a synthetic octapeptide zonulin-pathway antagonist studied for intestinal barrier stabilization and reduced permeability. It has been investigated most prominently in celiac disease and other barrier-disruption states relevant to IBS-like symptoms and inflammatory gut injury.

Key Benefits & Mechanisms

tight-junction-support

reduced-permeability

symptom-reduction

barrier-protection

Research Summary

Clinical and translational studies suggest larazotide can reduce antigen passage across the epithelium and improve gut barrier function. It is one of the better-known peptides for intestinal permeability and barrier-focused gastrointestinal therapy.

Related Peptides

Teduglutide

Teduglutide (glycyl-2 human glucagon-like peptide-2 analog)

Teduglutide is a GLP-2 analog that promotes intestinal growth, absorption, and mucosal repair. It is approved for short bowel syndrome and is one of the strongest peptide-based pro-restitution agents in gastrointestinal medicine.

Gastrointestinal

TFF3

Trefoil Factor 3 (intestinal trefoil factor)

Trefoil factor 3 is a small secreted peptide involved in epithelial restitution, mucus layer support, and mucosal healing. It is expressed in the intestine and has been studied in models of colitis, epithelial injury, and barrier dysfunction.

Gastrointestinal

Linaclotide

Linaclotide

A synthetic 14-amino-acid guanylate cyclase-C agonist used for chronic constipation and IBS-C. It increases intestinal fluid secretion and can improve stool frequency while indirectly shaping the luminal environment.

Gastrointestinal

Plecanatide

Plecanatide

A synthetic 16-amino-acid peptide and GC-C agonist related to uroguanylin. It is used to treat chronic idiopathic constipation and IBS-C by promoting intestinal secretion and softer stools.

Gastrointestinal