Linaclotide

14 Amino Acids · MW: 1526.8 Da

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Amino Acids

Molecular Weight

1526.8 Da

Half-life

Active locally; negligible systemic half-life

Research Score

5.0

Studies

1200

Storage

Store lyophilized at -20°C, reconstituted at 2-8°C

What is Linaclotide?

A synthetic 14-amino-acid guanylate cyclase-C agonist used for chronic constipation and IBS-C. It increases intestinal fluid secretion and can improve stool frequency while indirectly shaping the luminal environment.

Key Benefits & Mechanisms

improves-bowel-movements

reduces-abdominal-pain

increases-intestinal-secretion

supports-transit

Research Summary

Linaclotide has extensive clinical evidence for chronic idiopathic constipation and IBS-C, with consistent effects on stool frequency and abdominal symptom relief. Its mechanism is local GC-C activation in the gut with minimal systemic exposure.

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