TFF3 vs Glucagon-like peptide-2
Head-to-head comparison of TFF3 (Trefoil Factor 3 (intestinal trefoil factor)) and Glucagon-like peptide-2 (Glucagon-like peptide-2) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | TFF3 | Glucagon-like peptide-2 |
|---|---|---|
| Category | Gastrointestinal | Gastrointestinal |
| Full Name | Trefoil Factor 3 (intestinal trefoil factor) | Glucagon-like peptide-2 |
| Molecular Weight | 6370 Da | ~3.7 kDa |
| Half-Life | unknown; likely short in circulation | ~7 min |
| Amino Acids | 59 | 33 |
| Typical Dose | research-only; model-dependent microgram to milligram ranges | Research-only dosing varies; native peptide is not routinely used clinically |
| Route | Oral/Intrarectal | SC|IV |
| Purity | ≥98% | ≥98% |
| Studies Count | 70 | 90 |
| Research Status | Pre-clinical | Endogenous |
TFF3 Benefits
- ✓epithelial-restitution
- ✓mucus-support
- ✓wound-healing
- ✓barrier-stability
Glucagon-like peptide-2 Benefits
- ✓mucosal trophic support
- ✓intestinal barrier repair
- ✓nutrient absorption support
TFF3 Dosing
preclinical dosing varies widely by model|local or systemic administration|repeated dosing for inflammatory injury studies
Glucagon-like peptide-2 Dosing
0.5–2 mg/day (research)|SC/IV
TFF3 Side Effects
- ⚠limited human dosing data
- ⚠protein stability issues
- ⚠potential immunogenicity with exogenous use
Glucagon-like peptide-2 Side Effects
- ⚠nausea
- ⚠abdominal fullness
Research Overview
TFF3
TFF3 is a well-established mucosal repair factor in the literature, especially in the context of intestinal injury and inflammation. Experimental studies support a role in accelerating restitution and protecting the epithelial surface in gut disease models.
Glucagon-like peptide-2
Native GLP-2 is a key enteric growth factor with rapid degradation by DPP-4. Its therapeutic value is best known through GLP-2 analog development, but the native peptide itself is a real GI-relevant hormone.
Ready to buy?
Find both peptides from our verified, lab-tested vendors with purity certificates and third-party testing.