TFF3 vs Larazotide
Head-to-head comparison of TFF3 (Trefoil Factor 3 (intestinal trefoil factor)) and Larazotide (Larazotide acetate (AT-1001)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | TFF3 | Larazotide |
|---|---|---|
| Category | Gastrointestinal | Gastrointestinal |
| Full Name | Trefoil Factor 3 (intestinal trefoil factor) | Larazotide acetate (AT-1001) |
| Molecular Weight | 6370 Da | N/A |
| Half-Life | unknown; likely short in circulation | short; designed for local gut action |
| Amino Acids | 59 | 8 |
| Typical Dose | research-only; model-dependent microgram to milligram ranges | 0.5-4 mg TID (clinical studies) |
| Route | Oral/Intrarectal | Oral |
| Purity | ≥98% | ≥98% |
| Studies Count | 70 | 40 |
| Research Status | Pre-clinical | Clinical |
TFF3 Benefits
- ✓epithelial-restitution
- ✓mucus-support
- ✓wound-healing
- ✓barrier-stability
Larazotide Benefits
- ✓tight-junction-support
- ✓reduced-permeability
- ✓symptom-reduction
- ✓barrier-protection
TFF3 Dosing
preclinical dosing varies widely by model|local or systemic administration|repeated dosing for inflammatory injury studies
Larazotide Dosing
0.5-4 mg orally before meals in clinical trials|typically three times daily|short-course or chronic study protocols
TFF3 Side Effects
- ⚠limited human dosing data
- ⚠protein stability issues
- ⚠potential immunogenicity with exogenous use
Larazotide Side Effects
- ⚠headache
- ⚠nausea
- ⚠abdominal discomfort
Research Overview
TFF3
TFF3 is a well-established mucosal repair factor in the literature, especially in the context of intestinal injury and inflammation. Experimental studies support a role in accelerating restitution and protecting the epithelial surface in gut disease models.
Larazotide
Clinical and translational studies suggest larazotide can reduce antigen passage across the epithelium and improve gut barrier function. It is one of the better-known peptides for intestinal permeability and barrier-focused gastrointestinal therapy.
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