Larazotide vs Trefoil factor 2
Head-to-head comparison of Larazotide (Larazotide acetate (AT-1001)) and Trefoil factor 2 (Trefoil factor 2 (Spasmolytic Polypeptide)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Larazotide | Trefoil factor 2 |
|---|---|---|
| Category | Gastrointestinal | Gastrointestinal |
| Full Name | Larazotide acetate (AT-1001) | Trefoil factor 2 (Spasmolytic Polypeptide) |
| Molecular Weight | N/A | ≈11–12 kDa |
| Half-Life | short; designed for local gut action | Unknown |
| Amino Acids | 8 | 106 |
| Typical Dose | 0.5-4 mg TID (clinical studies) | none established |
| Route | Oral | oral/enteral|research-only |
| Purity | ≥98% | ≥98% |
| Studies Count | 40 | 80 |
| Research Status | Clinical | Pre-clinical |
Larazotide Benefits
- ✓tight-junction-support
- ✓reduced-permeability
- ✓symptom-reduction
- ✓barrier-protection
Trefoil factor 2 Benefits
- ✓epithelial restitution
- ✓barrier protection
- ✓ulcer healing
Larazotide Dosing
0.5-4 mg orally before meals in clinical trials|typically three times daily|short-course or chronic study protocols
Trefoil factor 2 Dosing
No established clinical dose|preclinical only
Larazotide Side Effects
- ⚠headache
- ⚠nausea
- ⚠abdominal discomfort
Trefoil factor 2 Side Effects
- ⚠limited human data
- ⚠theoretical growth-factor concerns
- ⚠GI discomfort
Research Overview
Larazotide
Clinical and translational studies suggest larazotide can reduce antigen passage across the epithelium and improve gut barrier function. It is one of the better-known peptides for intestinal permeability and barrier-focused gastrointestinal therapy.
Trefoil factor 2
TFF2 strengthens mucus-barrier repair and epithelial restitution after gastric injury in experimental systems, making it a well-known gastric-protective peptide.
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