Larazotide vs Teduglutide
Head-to-head comparison of Larazotide (Larazotide acetate (AT-1001)) and Teduglutide (Teduglutide (glycyl-2 human glucagon-like peptide-2 analog)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Larazotide | Teduglutide |
|---|---|---|
| Category | Gastrointestinal | Gastrointestinal |
| Full Name | Larazotide acetate (AT-1001) | Teduglutide (glycyl-2 human glucagon-like peptide-2 analog) |
| Molecular Weight | N/A | 3752 Da |
| Half-Life | short; designed for local gut action | approximately 2-3 hours |
| Amino Acids | 8 | 33 |
| Typical Dose | 0.5-4 mg TID (clinical studies) | 0.05 mg/kg/day |
| Route | Oral | Subcutaneous |
| Purity | ≥98% | ≥98% |
| Studies Count | 40 | 300 |
| Research Status | Clinical | Clinical |
Larazotide Benefits
- ✓tight-junction-support
- ✓reduced-permeability
- ✓symptom-reduction
- ✓barrier-protection
Teduglutide Benefits
- ✓mucosal-growth
- ✓absorption-support
- ✓barrier-repair
- ✓intestinal-adaptation
Larazotide Dosing
0.5-4 mg orally before meals in clinical trials|typically three times daily|short-course or chronic study protocols
Teduglutide Dosing
0.05 mg/kg once daily subcutaneous injection|chronic maintenance dosing in approved use|monitor fluid status and intestinal anatomy
Larazotide Side Effects
- ⚠headache
- ⚠nausea
- ⚠abdominal discomfort
Teduglutide Side Effects
- ⚠abdominal pain
- ⚠fluid retention
- ⚠polyp/neoplasia monitoring needed
Research Overview
Larazotide
Clinical and translational studies suggest larazotide can reduce antigen passage across the epithelium and improve gut barrier function. It is one of the better-known peptides for intestinal permeability and barrier-focused gastrointestinal therapy.
Teduglutide
Teduglutide has robust clinical evidence showing improved intestinal absorption and reduced parenteral nutrition dependence in short bowel syndrome. Its mechanism, via GLP-2 receptor activation, makes it highly relevant to mucosal healing and intestinal adaptation research.
Ready to buy?
Find both peptides from our verified, lab-tested vendors with purity certificates and third-party testing.