Larazotide vs Secretin
Head-to-head comparison of Larazotide (Larazotide acetate (AT-1001)) and Secretin (Human Secretin) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Larazotide | Secretin |
|---|---|---|
| Category | Gastrointestinal | Gastrointestinal |
| Full Name | Larazotide acetate (AT-1001) | Human Secretin |
| Molecular Weight | N/A | 3055.4 Da |
| Half-Life | short; designed for local gut action | 5-7 minutes |
| Amino Acids | 8 | 27 |
| Typical Dose | 0.5-4 mg TID (clinical studies) | 0.2 mcg/kg IV |
| Route | Oral | Intravenous |
| Purity | ≥98% | ≥98% |
| Studies Count | 40 | 800 |
| Research Status | Clinical | Clinical |
Larazotide Benefits
- ✓tight-junction-support
- ✓reduced-permeability
- ✓symptom-reduction
- ✓barrier-protection
Secretin Benefits
- ✓stimulates-pancreatic-secretion
- ✓supports-bicarbonate-release
- ✓aids-duodenal-pH-control
- ✓helps-digestive-coordination
Larazotide Dosing
0.5-4 mg orally before meals in clinical trials|typically three times daily|short-course or chronic study protocols
Secretin Dosing
0.2 mcg/kg IV diagnostic dose|research infusion protocols|short bolus administration
Larazotide Side Effects
- ⚠headache
- ⚠nausea
- ⚠abdominal discomfort
Secretin Side Effects
- ⚠flushing
- ⚠nausea
- ⚠abdominal-cramping
Research Overview
Larazotide
Clinical and translational studies suggest larazotide can reduce antigen passage across the epithelium and improve gut barrier function. It is one of the better-known peptides for intestinal permeability and barrier-focused gastrointestinal therapy.
Secretin
Secretin is a classic GI hormone with extensive physiology literature and established diagnostic use. It remains important for studying pancreatic secretory function, biliary responses, and duodenal feedback.
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