Larazotide vs TFF3
Head-to-head comparison of Larazotide (Larazotide acetate (AT-1001)) and TFF3 (Trefoil Factor 3 (intestinal trefoil factor)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Larazotide | TFF3 |
|---|---|---|
| Category | Gastrointestinal | Gastrointestinal |
| Full Name | Larazotide acetate (AT-1001) | Trefoil Factor 3 (intestinal trefoil factor) |
| Molecular Weight | N/A | 6370 Da |
| Half-Life | short; designed for local gut action | unknown; likely short in circulation |
| Amino Acids | 8 | 59 |
| Typical Dose | 0.5-4 mg TID (clinical studies) | research-only; model-dependent microgram to milligram ranges |
| Route | Oral | Oral/Intrarectal |
| Purity | ≥98% | ≥98% |
| Studies Count | 40 | 70 |
| Research Status | Clinical | Pre-clinical |
Larazotide Benefits
- ✓tight-junction-support
- ✓reduced-permeability
- ✓symptom-reduction
- ✓barrier-protection
TFF3 Benefits
- ✓epithelial-restitution
- ✓mucus-support
- ✓wound-healing
- ✓barrier-stability
Larazotide Dosing
0.5-4 mg orally before meals in clinical trials|typically three times daily|short-course or chronic study protocols
TFF3 Dosing
preclinical dosing varies widely by model|local or systemic administration|repeated dosing for inflammatory injury studies
Larazotide Side Effects
- ⚠headache
- ⚠nausea
- ⚠abdominal discomfort
TFF3 Side Effects
- ⚠limited human dosing data
- ⚠protein stability issues
- ⚠potential immunogenicity with exogenous use
Research Overview
Larazotide
Clinical and translational studies suggest larazotide can reduce antigen passage across the epithelium and improve gut barrier function. It is one of the better-known peptides for intestinal permeability and barrier-focused gastrointestinal therapy.
TFF3
TFF3 is a well-established mucosal repair factor in the literature, especially in the context of intestinal injury and inflammation. Experimental studies support a role in accelerating restitution and protecting the epithelial surface in gut disease models.
Ready to buy?
Find both peptides from our verified, lab-tested vendors with purity certificates and third-party testing.