TFF3 vs Trefoil factor 2
Head-to-head comparison of TFF3 (Trefoil Factor 3 (intestinal trefoil factor)) and Trefoil factor 2 (Trefoil factor 2 (Spasmolytic Polypeptide)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | TFF3 | Trefoil factor 2 |
|---|---|---|
| Category | Gastrointestinal | Gastrointestinal |
| Full Name | Trefoil Factor 3 (intestinal trefoil factor) | Trefoil factor 2 (Spasmolytic Polypeptide) |
| Molecular Weight | 6370 Da | ≈11–12 kDa |
| Half-Life | unknown; likely short in circulation | Unknown |
| Amino Acids | 59 | 106 |
| Typical Dose | research-only; model-dependent microgram to milligram ranges | none established |
| Route | Oral/Intrarectal | oral/enteral|research-only |
| Purity | ≥98% | ≥98% |
| Studies Count | 70 | 80 |
| Research Status | Pre-clinical | Pre-clinical |
TFF3 Benefits
- ✓epithelial-restitution
- ✓mucus-support
- ✓wound-healing
- ✓barrier-stability
Trefoil factor 2 Benefits
- ✓epithelial restitution
- ✓barrier protection
- ✓ulcer healing
TFF3 Dosing
preclinical dosing varies widely by model|local or systemic administration|repeated dosing for inflammatory injury studies
Trefoil factor 2 Dosing
No established clinical dose|preclinical only
TFF3 Side Effects
- ⚠limited human dosing data
- ⚠protein stability issues
- ⚠potential immunogenicity with exogenous use
Trefoil factor 2 Side Effects
- ⚠limited human data
- ⚠theoretical growth-factor concerns
- ⚠GI discomfort
Research Overview
TFF3
TFF3 is a well-established mucosal repair factor in the literature, especially in the context of intestinal injury and inflammation. Experimental studies support a role in accelerating restitution and protecting the epithelial surface in gut disease models.
Trefoil factor 2
TFF2 strengthens mucus-barrier repair and epithelial restitution after gastric injury in experimental systems, making it a well-known gastric-protective peptide.
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