Trefoil factor 2 vs Glucagon-like peptide-2
Head-to-head comparison of Trefoil factor 2 (Trefoil factor 2 (Spasmolytic Polypeptide)) and Glucagon-like peptide-2 (Glucagon-like peptide-2) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Trefoil factor 2 | Glucagon-like peptide-2 |
|---|---|---|
| Category | Gastrointestinal | Gastrointestinal |
| Full Name | Trefoil factor 2 (Spasmolytic Polypeptide) | Glucagon-like peptide-2 |
| Molecular Weight | ≈11–12 kDa | ~3.7 kDa |
| Half-Life | Unknown | ~7 min |
| Amino Acids | 106 | 33 |
| Typical Dose | none established | Research-only dosing varies; native peptide is not routinely used clinically |
| Route | oral/enteral|research-only | SC|IV |
| Purity | ≥98% | ≥98% |
| Studies Count | 80 | 90 |
| Research Status | Pre-clinical | Endogenous |
Trefoil factor 2 Benefits
- ✓epithelial restitution
- ✓barrier protection
- ✓ulcer healing
Glucagon-like peptide-2 Benefits
- ✓mucosal trophic support
- ✓intestinal barrier repair
- ✓nutrient absorption support
Trefoil factor 2 Dosing
No established clinical dose|preclinical only
Glucagon-like peptide-2 Dosing
0.5–2 mg/day (research)|SC/IV
Trefoil factor 2 Side Effects
- ⚠limited human data
- ⚠theoretical growth-factor concerns
- ⚠GI discomfort
Glucagon-like peptide-2 Side Effects
- ⚠nausea
- ⚠abdominal fullness
Research Overview
Trefoil factor 2
TFF2 strengthens mucus-barrier repair and epithelial restitution after gastric injury in experimental systems, making it a well-known gastric-protective peptide.
Glucagon-like peptide-2
Native GLP-2 is a key enteric growth factor with rapid degradation by DPP-4. Its therapeutic value is best known through GLP-2 analog development, but the native peptide itself is a real GI-relevant hormone.
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