Trefoil factor 2 vs TFF3
Head-to-head comparison of Trefoil factor 2 (Trefoil factor 2 (Spasmolytic Polypeptide)) and TFF3 (Trefoil Factor 3 (intestinal trefoil factor)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Trefoil factor 2 | TFF3 |
|---|---|---|
| Category | Gastrointestinal | Gastrointestinal |
| Full Name | Trefoil factor 2 (Spasmolytic Polypeptide) | Trefoil Factor 3 (intestinal trefoil factor) |
| Molecular Weight | ≈11–12 kDa | 6370 Da |
| Half-Life | Unknown | unknown; likely short in circulation |
| Amino Acids | 106 | 59 |
| Typical Dose | none established | research-only; model-dependent microgram to milligram ranges |
| Route | oral/enteral|research-only | Oral/Intrarectal |
| Purity | ≥98% | ≥98% |
| Studies Count | 80 | 70 |
| Research Status | Pre-clinical | Pre-clinical |
Trefoil factor 2 Benefits
- ✓epithelial restitution
- ✓barrier protection
- ✓ulcer healing
TFF3 Benefits
- ✓epithelial-restitution
- ✓mucus-support
- ✓wound-healing
- ✓barrier-stability
Trefoil factor 2 Dosing
No established clinical dose|preclinical only
TFF3 Dosing
preclinical dosing varies widely by model|local or systemic administration|repeated dosing for inflammatory injury studies
Trefoil factor 2 Side Effects
- ⚠limited human data
- ⚠theoretical growth-factor concerns
- ⚠GI discomfort
TFF3 Side Effects
- ⚠limited human dosing data
- ⚠protein stability issues
- ⚠potential immunogenicity with exogenous use
Research Overview
Trefoil factor 2
TFF2 strengthens mucus-barrier repair and epithelial restitution after gastric injury in experimental systems, making it a well-known gastric-protective peptide.
TFF3
TFF3 is a well-established mucosal repair factor in the literature, especially in the context of intestinal injury and inflammation. Experimental studies support a role in accelerating restitution and protecting the epithelial surface in gut disease models.
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