TFF3 vs Secretin
Head-to-head comparison of TFF3 (Trefoil Factor 3 (intestinal trefoil factor)) and Secretin (Human Secretin) — benefits, dosing, side effects, research data, and where to buy.
| Property | TFF3 | Secretin |
|---|---|---|
| Category | Gastrointestinal | Gastrointestinal |
| Full Name | Trefoil Factor 3 (intestinal trefoil factor) | Human Secretin |
| Molecular Weight | 6370 Da | 3055.4 Da |
| Half-Life | unknown; likely short in circulation | 5-7 minutes |
| Amino Acids | 59 | 27 |
| Typical Dose | research-only; model-dependent microgram to milligram ranges | 0.2 mcg/kg IV |
| Route | Oral/Intrarectal | Intravenous |
| Purity | ≥98% | ≥98% |
| Studies Count | 70 | 800 |
| Research Status | Pre-clinical | Clinical |
TFF3 Benefits
- ✓epithelial-restitution
- ✓mucus-support
- ✓wound-healing
- ✓barrier-stability
Secretin Benefits
- ✓stimulates-pancreatic-secretion
- ✓supports-bicarbonate-release
- ✓aids-duodenal-pH-control
- ✓helps-digestive-coordination
TFF3 Dosing
preclinical dosing varies widely by model|local or systemic administration|repeated dosing for inflammatory injury studies
Secretin Dosing
0.2 mcg/kg IV diagnostic dose|research infusion protocols|short bolus administration
TFF3 Side Effects
- ⚠limited human dosing data
- ⚠protein stability issues
- ⚠potential immunogenicity with exogenous use
Secretin Side Effects
- ⚠flushing
- ⚠nausea
- ⚠abdominal-cramping
Research Overview
TFF3
TFF3 is a well-established mucosal repair factor in the literature, especially in the context of intestinal injury and inflammation. Experimental studies support a role in accelerating restitution and protecting the epithelial surface in gut disease models.
Secretin
Secretin is a classic GI hormone with extensive physiology literature and established diagnostic use. It remains important for studying pancreatic secretory function, biliary responses, and duodenal feedback.
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