Secretin vs Trefoil factor 2
Head-to-head comparison of Secretin (Human Secretin) and Trefoil factor 2 (Trefoil factor 2 (Spasmolytic Polypeptide)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Secretin | Trefoil factor 2 |
|---|---|---|
| Category | Gastrointestinal | Gastrointestinal |
| Full Name | Human Secretin | Trefoil factor 2 (Spasmolytic Polypeptide) |
| Molecular Weight | 3055.4 Da | ≈11–12 kDa |
| Half-Life | 5-7 minutes | Unknown |
| Amino Acids | 27 | 106 |
| Typical Dose | 0.2 mcg/kg IV | none established |
| Route | Intravenous | oral/enteral|research-only |
| Purity | ≥98% | ≥98% |
| Studies Count | 800 | 80 |
| Research Status | Clinical | Pre-clinical |
Secretin Benefits
- ✓stimulates-pancreatic-secretion
- ✓supports-bicarbonate-release
- ✓aids-duodenal-pH-control
- ✓helps-digestive-coordination
Trefoil factor 2 Benefits
- ✓epithelial restitution
- ✓barrier protection
- ✓ulcer healing
Secretin Dosing
0.2 mcg/kg IV diagnostic dose|research infusion protocols|short bolus administration
Trefoil factor 2 Dosing
No established clinical dose|preclinical only
Secretin Side Effects
- ⚠flushing
- ⚠nausea
- ⚠abdominal-cramping
Trefoil factor 2 Side Effects
- ⚠limited human data
- ⚠theoretical growth-factor concerns
- ⚠GI discomfort
Research Overview
Secretin
Secretin is a classic GI hormone with extensive physiology literature and established diagnostic use. It remains important for studying pancreatic secretory function, biliary responses, and duodenal feedback.
Trefoil factor 2
TFF2 strengthens mucus-barrier repair and epithelial restitution after gastric injury in experimental systems, making it a well-known gastric-protective peptide.
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