Secretin vs Larazotide
Head-to-head comparison of Secretin (Human Secretin) and Larazotide (Larazotide acetate (AT-1001)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Secretin | Larazotide |
|---|---|---|
| Category | Gastrointestinal | Gastrointestinal |
| Full Name | Human Secretin | Larazotide acetate (AT-1001) |
| Molecular Weight | 3055.4 Da | N/A |
| Half-Life | 5-7 minutes | short; designed for local gut action |
| Amino Acids | 27 | 8 |
| Typical Dose | 0.2 mcg/kg IV | 0.5-4 mg TID (clinical studies) |
| Route | Intravenous | Oral |
| Purity | ≥98% | ≥98% |
| Studies Count | 800 | 40 |
| Research Status | Clinical | Clinical |
Secretin Benefits
- ✓stimulates-pancreatic-secretion
- ✓supports-bicarbonate-release
- ✓aids-duodenal-pH-control
- ✓helps-digestive-coordination
Larazotide Benefits
- ✓tight-junction-support
- ✓reduced-permeability
- ✓symptom-reduction
- ✓barrier-protection
Secretin Dosing
0.2 mcg/kg IV diagnostic dose|research infusion protocols|short bolus administration
Larazotide Dosing
0.5-4 mg orally before meals in clinical trials|typically three times daily|short-course or chronic study protocols
Secretin Side Effects
- ⚠flushing
- ⚠nausea
- ⚠abdominal-cramping
Larazotide Side Effects
- ⚠headache
- ⚠nausea
- ⚠abdominal discomfort
Research Overview
Secretin
Secretin is a classic GI hormone with extensive physiology literature and established diagnostic use. It remains important for studying pancreatic secretory function, biliary responses, and duodenal feedback.
Larazotide
Clinical and translational studies suggest larazotide can reduce antigen passage across the epithelium and improve gut barrier function. It is one of the better-known peptides for intestinal permeability and barrier-focused gastrointestinal therapy.
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