Trefoil factor 2 vs Motilin
Head-to-head comparison of Trefoil factor 2 (Trefoil factor 2 (Spasmolytic Polypeptide)) and Motilin (Motilin) — benefits, dosing, side effects, research data, and where to buy.
Research Score
Motilin
4.3
| Property | Trefoil factor 2 | Motilin |
|---|---|---|
| Category | Gastrointestinal | Gastrointestinal |
| Full Name | Trefoil factor 2 (Spasmolytic Polypeptide) | Motilin |
| Molecular Weight | ≈11–12 kDa | ~2.7 kDa |
| Half-Life | Unknown | ~20 min |
| Amino Acids | 106 | 22 |
| Typical Dose | none established | No standard approved dose; experimental use only |
| Route | oral/enteral|research-only | IV|SC |
| Purity | ≥98% | ≥98% |
| Studies Count | 80 | 81 |
| Research Status | Pre-clinical | Endogenous |
Trefoil factor 2 Benefits
- ✓epithelial restitution
- ✓barrier protection
- ✓ulcer healing
Motilin Benefits
- ✓migrating motor complex support
- ✓gastric emptying
- ✓small-bowel clearance
Trefoil factor 2 Dosing
No established clinical dose|preclinical only
Motilin Dosing
0.1–1 mg (experimental)|IV/SC
Trefoil factor 2 Side Effects
- ⚠limited human data
- ⚠theoretical growth-factor concerns
- ⚠GI discomfort
Motilin Side Effects
- ⚠cramping
- ⚠nausea
Research Overview
Trefoil factor 2
TFF2 strengthens mucus-barrier repair and epithelial restitution after gastric injury in experimental systems, making it a well-known gastric-protective peptide.
Motilin
Motilin is a 22-amino-acid peptide released from the upper small intestine and is one of the classic physiologic prokinetic signals. It is a real peptide target for GI motility research, though not commonly used as a standard drug.
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Common Stacking Partners
Trefoil factor 2 stacks with:
TFF2spasmolytic polypeptide
Motilin stacks with:
MLNmotilin
gastrointestinalgastric-protectionmucosal-repairmotilityprokineticgastric-emptying