Motilin
Motilin
22 Amino Acids · MW: ~2.7 kDa
Amino Acids
22
Molecular Weight
~2.7 kDa
Half-life
~20 min
Research Score
4.3
Studies
81
Storage
Store lyophilized at -20°C, reconstituted at 2-8°C
What is Motilin?
Endogenous GI hormone that stimulates the migrating motor complex and helps coordinate fasting-phase motility. It is relevant to delayed gastric emptying, dysmotility, and constipation-predominant syndromes.
Key Benefits & Mechanisms
migrating motor complex support
gastric emptying
small-bowel clearance
Research Summary
Motilin is a 22-amino-acid peptide released from the upper small intestine and is one of the classic physiologic prokinetic signals. It is a real peptide target for GI motility research, though not commonly used as a standard drug.
Related Peptides
Larazotide
Larazotide acetate (AT-1001)
Larazotide acetate is a synthetic octapeptide zonulin-pathway antagonist studied for intestinal barrier stabilization and reduced permeability. It has been investigated most prominently in celiac disease and other barrier-disruption states relevant to IBS-like symptoms and inflammatory gut injury.
GastrointestinalTeduglutide
Teduglutide (glycyl-2 human glucagon-like peptide-2 analog)
Teduglutide is a GLP-2 analog that promotes intestinal growth, absorption, and mucosal repair. It is approved for short bowel syndrome and is one of the strongest peptide-based pro-restitution agents in gastrointestinal medicine.
GastrointestinalTFF3
Trefoil Factor 3 (intestinal trefoil factor)
Trefoil factor 3 is a small secreted peptide involved in epithelial restitution, mucus layer support, and mucosal healing. It is expressed in the intestine and has been studied in models of colitis, epithelial injury, and barrier dysfunction.
GastrointestinalLinaclotide
Linaclotide
A synthetic 14-amino-acid guanylate cyclase-C agonist used for chronic constipation and IBS-C. It increases intestinal fluid secretion and can improve stool frequency while indirectly shaping the luminal environment.
Gastrointestinal