Glucagon-like peptide-2
Glucagon-like peptide-2
33 Amino Acids · MW: ~3.7 kDa
Amino Acids
33
Molecular Weight
~3.7 kDa
Half-life
~7 min
Research Score
4.6
Studies
90
Storage
Store lyophilized at -20°C, reconstituted at 2-8°C
What is Glucagon-like peptide-2?
Endogenous intestinal trophic peptide that helps preserve mucosal architecture and absorption. It is studied for short bowel syndrome, barrier repair, and support of gut recovery after injury.
Key Benefits & Mechanisms
mucosal trophic support
intestinal barrier repair
nutrient absorption support
Research Summary
Native GLP-2 is a key enteric growth factor with rapid degradation by DPP-4. Its therapeutic value is best known through GLP-2 analog development, but the native peptide itself is a real GI-relevant hormone.
Related Peptides
Larazotide
Larazotide acetate (AT-1001)
Larazotide acetate is a synthetic octapeptide zonulin-pathway antagonist studied for intestinal barrier stabilization and reduced permeability. It has been investigated most prominently in celiac disease and other barrier-disruption states relevant to IBS-like symptoms and inflammatory gut injury.
GastrointestinalTeduglutide
Teduglutide (glycyl-2 human glucagon-like peptide-2 analog)
Teduglutide is a GLP-2 analog that promotes intestinal growth, absorption, and mucosal repair. It is approved for short bowel syndrome and is one of the strongest peptide-based pro-restitution agents in gastrointestinal medicine.
GastrointestinalTFF3
Trefoil Factor 3 (intestinal trefoil factor)
Trefoil factor 3 is a small secreted peptide involved in epithelial restitution, mucus layer support, and mucosal healing. It is expressed in the intestine and has been studied in models of colitis, epithelial injury, and barrier dysfunction.
GastrointestinalLinaclotide
Linaclotide
A synthetic 14-amino-acid guanylate cyclase-C agonist used for chronic constipation and IBS-C. It increases intestinal fluid secretion and can improve stool frequency while indirectly shaping the luminal environment.
Gastrointestinal