Cholecystokinin-8 vs Teduglutide

Head-to-head comparison of Cholecystokinin-8 (Cholecystokinin (sulfated C-terminal octapeptide, CCK-8)) and Teduglutide (Teduglutide (glycyl-2 human glucagon-like peptide-2 analog)) — benefits, dosing, side effects, research data, and where to buy.

PropertyCholecystokinin-8Teduglutide
CategoryEndocrine PeptidesGastrointestinal
Full NameCholecystokinin (sulfated C-terminal octapeptide, CCK-8)Teduglutide (glycyl-2 human glucagon-like peptide-2 analog)
Molecular Weight1143.2 Da3752 Da
Half-Life1-2 minapproximately 2-3 hours
Amino AcidsDY(SO3H)MGWMDF-NH233
Typical Dosephysiologic low-picomolar-nanomolar range|research-dependent0.05 mg/kg/day
Routeendogenous secretion|research IV/SCSubcutaneous
Purity≥98%≥98%
Studies Count97300
Research StatusEndogenousClinical

Cholecystokinin-8 Benefits

  • gallbladder contraction
  • pancreatic enzyme release
  • satiety signaling

Teduglutide Benefits

  • mucosal-growth
  • absorption-support
  • barrier-repair
  • intestinal-adaptation

Cholecystokinin-8 Dosing

physiologic secretion|research-dependent

Teduglutide Dosing

0.05 mg/kg once daily subcutaneous injection|chronic maintenance dosing in approved use|monitor fluid status and intestinal anatomy

Cholecystokinin-8 Side Effects

  • abdominal cramping
  • nausea
  • biliary contraction

Teduglutide Side Effects

  • abdominal pain
  • fluid retention
  • polyp/neoplasia monitoring needed

Research Overview

Cholecystokinin-8

CCK-8 is a canonical gut hormone fragment with extensive documentation in digestive physiology and appetite control. Sulfation of the tyrosine residue is important for high-affinity receptor activity.

Teduglutide

Teduglutide has robust clinical evidence showing improved intestinal absorption and reduced parenteral nutrition dependence in short bowel syndrome. Its mechanism, via GLP-2 receptor activation, makes it highly relevant to mucosal healing and intestinal adaptation research.

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Common Stacking Partners

Cholecystokinin-8 stacks with:

gallbladderpancreassatiety

Teduglutide stacks with:

nutritional-supportoral-rehydrationprobiotics
gut-hormonesatiety-peptideendocrine-peptideshort-bowelmucosal-healingabsorptionintestinal-adaptationGLP-2