Cholecystokinin-8 vs Plecanatide
Head-to-head comparison of Cholecystokinin-8 (Cholecystokinin (sulfated C-terminal octapeptide, CCK-8)) and Plecanatide (Plecanatide) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Cholecystokinin-8 | Plecanatide |
|---|---|---|
| Category | Endocrine Peptides | Gastrointestinal |
| Full Name | Cholecystokinin (sulfated C-terminal octapeptide, CCK-8) | Plecanatide |
| Molecular Weight | 1143.2 Da | Approx. 1620 Da |
| Half-Life | 1-2 min | Local intestinal action; systemic half-life not clinically meaningful |
| Amino Acids | DY(SO3H)MGWMDF-NH2 | 16 |
| Typical Dose | physiologic low-picomolar-nanomolar range|research-dependent | 3 mg once daily |
| Route | endogenous secretion|research IV/SC | Oral |
| Purity | ≥98% | ≥98% |
| Studies Count | 97 | 350 |
| Research Status | Endogenous | Clinical |
Cholecystokinin-8 Benefits
- ✓gallbladder contraction
- ✓pancreatic enzyme release
- ✓satiety signaling
Plecanatide Benefits
- ✓improves-stool-frequency
- ✓supports-fluid-secretion
- ✓may-reduce-constipation
- ✓local-gut-action
Cholecystokinin-8 Dosing
physiologic secretion|research-dependent
Plecanatide Dosing
3 mg PO daily|take with or without food|avoid when dehydrated
Cholecystokinin-8 Side Effects
- ⚠abdominal cramping
- ⚠nausea
- ⚠biliary contraction
Plecanatide Side Effects
- ⚠diarrhea
- ⚠abdominal-discomfort
- ⚠nausea
Research Overview
Cholecystokinin-8
CCK-8 is a canonical gut hormone fragment with extensive documentation in digestive physiology and appetite control. Sulfation of the tyrosine residue is important for high-affinity receptor activity.
Plecanatide
Clinical trials show plecanatide improves constipation outcomes with a generally favorable tolerability profile. Like linaclotide, it acts locally in the intestinal lumen via GC-C signaling rather than systemic hormone effects.
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