Huwentoxin-IV vs Kahalalide F
Head-to-head comparison of Huwentoxin-IV (Huwentoxin-IV from Selenocosmia huwena venom) and Kahalalide F (Kahalalide F) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Huwentoxin-IV | Kahalalide F |
|---|---|---|
| Category | Experimental | Experimental |
| Full Name | Huwentoxin-IV from Selenocosmia huwena venom | Kahalalide F |
| Molecular Weight | 4,000 Da | 1111.3 Da |
| Half-Life | Minutes to hours | N/A |
| Amino Acids | 35 | N/A |
| Typical Dose | 0.01-1 nmol intrathecal|1-100 nM in vitro|single-dose rodent studies | 0.1-3 mg/m2 IV in early trials |
| Route | Intrathecal | Intravenous |
| Purity | ≥98% | ≥98% |
| Studies Count | 110 | 85 |
| Research Status | Pre-clinical | Pre-clinical |
Huwentoxin-IV Benefits
- ✓Nav1.7 selectivity
- ✓pain-channel validation
- ✓action-potential research
- ✓analgesic lead optimization
Kahalalide F Benefits
- ✓antineoplastic
- ✓pro-apoptotic
- ✓membrane-active
- ✓anti-proliferative
Huwentoxin-IV Dosing
In vitro Nav1.7 electrophysiology|Intrathecal rodent analgesia studies|Single-bolus channel selectivity assays
Kahalalide F Dosing
IV infusion in phase I oncology studies|dose escalation used in trials|preclinical nanomolar assays
Huwentoxin-IV Side Effects
- ⚠Neurological impairment at high exposure
- ⚠off-target sodium-channel effects
- ⚠injection-site irritation
Kahalalide F Side Effects
- ⚠fatigue
- ⚠nausea
- ⚠transaminase elevation
Research Overview
Huwentoxin-IV
Studies show huwentoxin-IV can inhibit sodium-channel currents with notable selectivity, making it useful for dissecting pain-sensing neuron excitability. It is one of the better known spider-venom templates for Nav1.7-targeted drug discovery.
Kahalalide F
Kahalalide F was investigated in multiple preclinical and early clinical cancer studies because of its unusual membrane-disrupting and anti-tumor effects. Development highlighted the promise and limits of marine depsipeptides as oncology leads.
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