Kahalalide F vs Plitidepsin

Head-to-head comparison of Kahalalide F (Kahalalide F) and Plitidepsin (Dehydrodidemnin B (Plitidepsin)) — benefits, dosing, side effects, research data, and where to buy.

Research Score

PropertyKahalalide FPlitidepsin
CategoryExperimentalExperimental
Full NameKahalalide FDehydrodidemnin B (Plitidepsin)
Molecular Weight1111.3 Da1110.3 Da
Half-LifeN/AApproximately 44 hours
Amino AcidsN/AN/A
Typical Dose0.1-3 mg/m2 IV in early trials1.5 mg/m2 IV
RouteIntravenousIntravenous
Purity≥98%≥98%
Studies Count85240
Research StatusPre-clinicalClinical

Kahalalide F Benefits

  • antineoplastic
  • pro-apoptotic
  • membrane-active
  • anti-proliferative

Plitidepsin Benefits

  • antineoplastic
  • antiviral
  • pro-apoptotic
  • anti-inflammatory

Kahalalide F Dosing

IV infusion in phase I oncology studies|dose escalation used in trials|preclinical nanomolar assays

Plitidepsin Dosing

1.5 mg/m2 IV infusion in oncology trials|q21d or similar intermittent schedules|dose escalation and combination protocols in studies

Kahalalide F Side Effects

  • fatigue
  • nausea
  • transaminase elevation

Plitidepsin Side Effects

  • nausea
  • fatigue
  • transaminase elevation

Research Overview

Kahalalide F

Kahalalide F was investigated in multiple preclinical and early clinical cancer studies because of its unusual membrane-disrupting and anti-tumor effects. Development highlighted the promise and limits of marine depsipeptides as oncology leads.

Plitidepsin

Plitidepsin has been studied for its ability to disrupt eEF1A-dependent pathways, induce oxidative stress, and suppress tumor cell growth. It has reached clinical oncology development and was also evaluated as a candidate against SARS-CoV-2 in the literature.

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Common Stacking Partners

Kahalalide F stacks with:

paclitaxelcisplatincarboplatin

Plitidepsin stacks with:

dexamethasonebortezomibgemcitabine
marine-derivedsea-slugdepsipeptideoncologytunicateanticancer