Plitidepsin vs SNX-482
Head-to-head comparison of Plitidepsin (Dehydrodidemnin B (Plitidepsin)) and SNX-482 (SNX-482 peptide from Hysterocrates gigas venom) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Plitidepsin | SNX-482 |
|---|---|---|
| Category | Experimental | Experimental |
| Full Name | Dehydrodidemnin B (Plitidepsin) | SNX-482 peptide from Hysterocrates gigas venom |
| Molecular Weight | 1110.3 Da | 4,300 Da |
| Half-Life | Approximately 44 hours | Minutes to hours |
| Amino Acids | N/A | 41 |
| Typical Dose | 1.5 mg/m2 IV | 0.01-1 nmol intrathecal|1-100 nM in vitro|single-dose electrophysiology studies |
| Route | Intravenous | Intrathecal |
| Purity | ≥98% | ≥98% |
| Studies Count | 240 | 85 |
| Research Status | Clinical | Pre-clinical |
Plitidepsin Benefits
- ✓antineoplastic
- ✓antiviral
- ✓pro-apoptotic
- ✓anti-inflammatory
SNX-482 Benefits
- ✓Cav2.3 blockade
- ✓synaptic transmission studies
- ✓excitability mapping
- ✓pain and epilepsy research
Plitidepsin Dosing
1.5 mg/m2 IV infusion in oncology trials|q21d or similar intermittent schedules|dose escalation and combination protocols in studies
SNX-482 Dosing
Patch-clamp Cav2.3 assays|Intrathecal neurophysiology studies|Acute channel-blockade experiments
Plitidepsin Side Effects
- ⚠nausea
- ⚠fatigue
- ⚠transaminase elevation
SNX-482 Side Effects
- ⚠Ataxia at high exposure
- ⚠off-target calcium-channel block
- ⚠cardiovascular effects in animal models
Research Overview
Plitidepsin
Plitidepsin has been studied for its ability to disrupt eEF1A-dependent pathways, induce oxidative stress, and suppress tumor cell growth. It has reached clinical oncology development and was also evaluated as a candidate against SARS-CoV-2 in the literature.
SNX-482
SNX-482 has been used to dissect R-type calcium currents in neurons and endocrine cells, and to map the role of Cav2.3 in excitability. Its selectivity profile has made it a standard research reagent in channel pharmacology.
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