SNX-482 vs Kahalalide F
Head-to-head comparison of SNX-482 (SNX-482 peptide from Hysterocrates gigas venom) and Kahalalide F (Kahalalide F) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | SNX-482 | Kahalalide F |
|---|---|---|
| Category | Experimental | Experimental |
| Full Name | SNX-482 peptide from Hysterocrates gigas venom | Kahalalide F |
| Molecular Weight | 4,300 Da | 1111.3 Da |
| Half-Life | Minutes to hours | N/A |
| Amino Acids | 41 | N/A |
| Typical Dose | 0.01-1 nmol intrathecal|1-100 nM in vitro|single-dose electrophysiology studies | 0.1-3 mg/m2 IV in early trials |
| Route | Intrathecal | Intravenous |
| Purity | ≥98% | ≥98% |
| Studies Count | 85 | 85 |
| Research Status | Pre-clinical | Pre-clinical |
SNX-482 Benefits
- ✓Cav2.3 blockade
- ✓synaptic transmission studies
- ✓excitability mapping
- ✓pain and epilepsy research
Kahalalide F Benefits
- ✓antineoplastic
- ✓pro-apoptotic
- ✓membrane-active
- ✓anti-proliferative
SNX-482 Dosing
Patch-clamp Cav2.3 assays|Intrathecal neurophysiology studies|Acute channel-blockade experiments
Kahalalide F Dosing
IV infusion in phase I oncology studies|dose escalation used in trials|preclinical nanomolar assays
SNX-482 Side Effects
- ⚠Ataxia at high exposure
- ⚠off-target calcium-channel block
- ⚠cardiovascular effects in animal models
Kahalalide F Side Effects
- ⚠fatigue
- ⚠nausea
- ⚠transaminase elevation
Research Overview
SNX-482
SNX-482 has been used to dissect R-type calcium currents in neurons and endocrine cells, and to map the role of Cav2.3 in excitability. Its selectivity profile has made it a standard research reagent in channel pharmacology.
Kahalalide F
Kahalalide F was investigated in multiple preclinical and early clinical cancer studies because of its unusual membrane-disrupting and anti-tumor effects. Development highlighted the promise and limits of marine depsipeptides as oncology leads.
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