SNX-482 vs Huwentoxin-IV
Head-to-head comparison of SNX-482 (SNX-482 peptide from Hysterocrates gigas venom) and Huwentoxin-IV (Huwentoxin-IV from Selenocosmia huwena venom) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | SNX-482 | Huwentoxin-IV |
|---|---|---|
| Category | Experimental | Experimental |
| Full Name | SNX-482 peptide from Hysterocrates gigas venom | Huwentoxin-IV from Selenocosmia huwena venom |
| Molecular Weight | 4,300 Da | 4,000 Da |
| Half-Life | Minutes to hours | Minutes to hours |
| Amino Acids | 41 | 35 |
| Typical Dose | 0.01-1 nmol intrathecal|1-100 nM in vitro|single-dose electrophysiology studies | 0.01-1 nmol intrathecal|1-100 nM in vitro|single-dose rodent studies |
| Route | Intrathecal | Intrathecal |
| Purity | ≥98% | ≥98% |
| Studies Count | 85 | 110 |
| Research Status | Pre-clinical | Pre-clinical |
SNX-482 Benefits
- ✓Cav2.3 blockade
- ✓synaptic transmission studies
- ✓excitability mapping
- ✓pain and epilepsy research
Huwentoxin-IV Benefits
- ✓Nav1.7 selectivity
- ✓pain-channel validation
- ✓action-potential research
- ✓analgesic lead optimization
SNX-482 Dosing
Patch-clamp Cav2.3 assays|Intrathecal neurophysiology studies|Acute channel-blockade experiments
Huwentoxin-IV Dosing
In vitro Nav1.7 electrophysiology|Intrathecal rodent analgesia studies|Single-bolus channel selectivity assays
SNX-482 Side Effects
- ⚠Ataxia at high exposure
- ⚠off-target calcium-channel block
- ⚠cardiovascular effects in animal models
Huwentoxin-IV Side Effects
- ⚠Neurological impairment at high exposure
- ⚠off-target sodium-channel effects
- ⚠injection-site irritation
Research Overview
SNX-482
SNX-482 has been used to dissect R-type calcium currents in neurons and endocrine cells, and to map the role of Cav2.3 in excitability. Its selectivity profile has made it a standard research reagent in channel pharmacology.
Huwentoxin-IV
Studies show huwentoxin-IV can inhibit sodium-channel currents with notable selectivity, making it useful for dissecting pain-sensing neuron excitability. It is one of the better known spider-venom templates for Nav1.7-targeted drug discovery.
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