Huwentoxin-IV vs Dolastatin 10
Head-to-head comparison of Huwentoxin-IV (Huwentoxin-IV from Selenocosmia huwena venom) and Dolastatin 10 (Dolastatin 10) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Huwentoxin-IV | Dolastatin 10 |
|---|---|---|
| Category | Experimental | Experimental |
| Full Name | Huwentoxin-IV from Selenocosmia huwena venom | Dolastatin 10 |
| Molecular Weight | 4,000 Da | 771.0 Da |
| Half-Life | Minutes to hours | N/A |
| Amino Acids | 35 | 5 |
| Typical Dose | 0.01-1 nmol intrathecal|1-100 nM in vitro|single-dose rodent studies | N/A in humans; subnanomolar to low-nanomolar in vitro |
| Route | Intrathecal | Intravenous |
| Purity | ≥98% | ≥98% |
| Studies Count | 110 | 300 |
| Research Status | Pre-clinical | Pre-clinical |
Huwentoxin-IV Benefits
- ✓Nav1.7 selectivity
- ✓pain-channel validation
- ✓action-potential research
- ✓analgesic lead optimization
Dolastatin 10 Benefits
- ✓antineoplastic
- ✓microtubule disruption
- ✓antimitotic
- ✓ADC payload scaffold
Huwentoxin-IV Dosing
In vitro Nav1.7 electrophysiology|Intrathecal rodent analgesia studies|Single-bolus channel selectivity assays
Dolastatin 10 Dosing
research-grade in vitro nanomolar use|early IV oncology exploration|no approved dosing regimen
Huwentoxin-IV Side Effects
- ⚠Neurological impairment at high exposure
- ⚠off-target sodium-channel effects
- ⚠injection-site irritation
Dolastatin 10 Side Effects
- ⚠peripheral neuropathy
- ⚠neutropenia
- ⚠fatigue
Research Overview
Huwentoxin-IV
Studies show huwentoxin-IV can inhibit sodium-channel currents with notable selectivity, making it useful for dissecting pain-sensing neuron excitability. It is one of the better known spider-venom templates for Nav1.7-targeted drug discovery.
Dolastatin 10
Dolastatin 10 became famous for extreme cytotoxic potency and its ability to block tubulin polymerization. Although the native compound itself did not become a standard therapy, it inspired a major class of clinically important auristatin-based payloads.
Ready to buy?
Find both peptides from our verified, lab-tested vendors with purity certificates and third-party testing.