Huwentoxin-IV vs Conantokin-G
Head-to-head comparison of Huwentoxin-IV (Huwentoxin-IV from Selenocosmia huwena venom) and Conantokin-G (Conantokin-G from Conus geographus venom) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Huwentoxin-IV | Conantokin-G |
|---|---|---|
| Category | Experimental | Experimental |
| Full Name | Huwentoxin-IV from Selenocosmia huwena venom | Conantokin-G from Conus geographus venom |
| Molecular Weight | 4,000 Da | 2,150 Da |
| Half-Life | Minutes to hours | Minutes to hours |
| Amino Acids | 35 | 17 |
| Typical Dose | 0.01-1 nmol intrathecal|1-100 nM in vitro|single-dose rodent studies | 0.1-10 nmol intrathecal|10-1000 nM in vitro|single-dose rodent studies |
| Route | Intrathecal | Intrathecal |
| Purity | ≥98% | ≥98% |
| Studies Count | 110 | 95 |
| Research Status | Pre-clinical | Pre-clinical |
Huwentoxin-IV Benefits
- ✓Nav1.7 selectivity
- ✓pain-channel validation
- ✓action-potential research
- ✓analgesic lead optimization
Conantokin-G Benefits
- ✓NMDA receptor antagonism
- ✓seizure-model research
- ✓excitatory neurotransmission mapping
- ✓pain-mechanism studies
Huwentoxin-IV Dosing
In vitro Nav1.7 electrophysiology|Intrathecal rodent analgesia studies|Single-bolus channel selectivity assays
Conantokin-G Dosing
Intrathecal administration in seizure/pain models|NMDA receptor assays|In vitro excitation studies
Huwentoxin-IV Side Effects
- ⚠Neurological impairment at high exposure
- ⚠off-target sodium-channel effects
- ⚠injection-site irritation
Conantokin-G Side Effects
- ⚠Sedation or dizziness in animals
- ⚠motor effects at high exposure
- ⚠off-target NMDA modulation
Research Overview
Huwentoxin-IV
Studies show huwentoxin-IV can inhibit sodium-channel currents with notable selectivity, making it useful for dissecting pain-sensing neuron excitability. It is one of the better known spider-venom templates for Nav1.7-targeted drug discovery.
Conantokin-G
Research has shown conantokin-G can suppress NMDA-mediated responses in a sequence- and modification-dependent manner. It remains a classic marine peptide tool for probing glutamatergic signaling and analgesia-related pathways.
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