Huwentoxin-IV vs SNX-482
Head-to-head comparison of Huwentoxin-IV (Huwentoxin-IV from Selenocosmia huwena venom) and SNX-482 (SNX-482 peptide from Hysterocrates gigas venom) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Huwentoxin-IV | SNX-482 |
|---|---|---|
| Category | Experimental | Experimental |
| Full Name | Huwentoxin-IV from Selenocosmia huwena venom | SNX-482 peptide from Hysterocrates gigas venom |
| Molecular Weight | 4,000 Da | 4,300 Da |
| Half-Life | Minutes to hours | Minutes to hours |
| Amino Acids | 35 | 41 |
| Typical Dose | 0.01-1 nmol intrathecal|1-100 nM in vitro|single-dose rodent studies | 0.01-1 nmol intrathecal|1-100 nM in vitro|single-dose electrophysiology studies |
| Route | Intrathecal | Intrathecal |
| Purity | ≥98% | ≥98% |
| Studies Count | 110 | 85 |
| Research Status | Pre-clinical | Pre-clinical |
Huwentoxin-IV Benefits
- ✓Nav1.7 selectivity
- ✓pain-channel validation
- ✓action-potential research
- ✓analgesic lead optimization
SNX-482 Benefits
- ✓Cav2.3 blockade
- ✓synaptic transmission studies
- ✓excitability mapping
- ✓pain and epilepsy research
Huwentoxin-IV Dosing
In vitro Nav1.7 electrophysiology|Intrathecal rodent analgesia studies|Single-bolus channel selectivity assays
SNX-482 Dosing
Patch-clamp Cav2.3 assays|Intrathecal neurophysiology studies|Acute channel-blockade experiments
Huwentoxin-IV Side Effects
- ⚠Neurological impairment at high exposure
- ⚠off-target sodium-channel effects
- ⚠injection-site irritation
SNX-482 Side Effects
- ⚠Ataxia at high exposure
- ⚠off-target calcium-channel block
- ⚠cardiovascular effects in animal models
Research Overview
Huwentoxin-IV
Studies show huwentoxin-IV can inhibit sodium-channel currents with notable selectivity, making it useful for dissecting pain-sensing neuron excitability. It is one of the better known spider-venom templates for Nav1.7-targeted drug discovery.
SNX-482
SNX-482 has been used to dissect R-type calcium currents in neurons and endocrine cells, and to map the role of Cav2.3 in excitability. Its selectivity profile has made it a standard research reagent in channel pharmacology.
Ready to buy?
Find both peptides from our verified, lab-tested vendors with purity certificates and third-party testing.