Huwentoxin-IV
Huwentoxin-IV from Selenocosmia huwena venom
35 Amino Acids · MW: 4,000 Da
Amino Acids
35
Molecular Weight
4,000 Da
Half-life
Minutes to hours
Research Score
4.7
Studies
110
Storage
Store lyophilized at -20°C, reconstituted at 2-8°C
What is Huwentoxin-IV?
Huwentoxin-IV is a spider venom peptide that potently targets voltage-gated sodium channels, with strong interest around Nav1.7. It is widely used as a tool compound for ion-channel pharmacology and analgesic discovery.
Key Benefits & Mechanisms
Nav1.7 selectivity
pain-channel validation
action-potential research
analgesic lead optimization
Research Summary
Studies show huwentoxin-IV can inhibit sodium-channel currents with notable selectivity, making it useful for dissecting pain-sensing neuron excitability. It is one of the better known spider-venom templates for Nav1.7-targeted drug discovery.
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Experimental