Mambalgin-1
Mambalgin-1 from Dendroaspis polylepis venom
57 Amino Acids · MW: 6,300 Da
Amino Acids
57
Molecular Weight
6,300 Da
Half-life
Minutes to hours
Research Score
4.5
Studies
55
Storage
Store lyophilized at -20°C, reconstituted at 2-8°C
What is Mambalgin-1?
Mambalgin-1 is a three-finger snake venom peptide that inhibits acid-sensing ion channels (ASICs), especially ASIC1a and ASIC1b. It is studied as a non-opioid analgesic lead with strong mechanistic value in sensory neuroscience.
Key Benefits & Mechanisms
ASIC channel inhibition
non-opioid analgesia research
sensory-neuron physiology
lead optimization for pain therapeutics
Research Summary
Pre-clinical work shows mambalgin-1 can reduce pain behaviors by modulating proton-gated ion channels in peripheral and central pathways. It has become an important template for developing ASIC-targeted analgesics.
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