RgIA
alpha-Conotoxin RgIA from Conus regius venom
13 Amino Acids · MW: 1,670 Da
Amino Acids
13
Molecular Weight
1,670 Da
Half-life
Minutes to hours
Research Score
4.8
Studies
130
Storage
Store lyophilized at -20°C, reconstituted at 2-8°C
What is RgIA?
RgIA is a disulfide-rich cone snail peptide that selectively antagonizes the alpha9alpha10 nicotinic acetylcholine receptor. It is used as a research tool in pain and neuroimmune signaling studies and as a pre-clinical analgesic lead.
Key Benefits & Mechanisms
alpha9alpha10 nAChR selectivity
neuropathic pain model tool
neuroimmune signaling research
analgesic lead discovery
Research Summary
Scientific studies show RgIA can strongly inhibit alpha9alpha10 nicotinic signaling with high selectivity compared with many other nAChR ligands. It is widely used to probe peripheral sensory pathways and inflammation-linked pain mechanisms.
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Experimental