Conantokin-G
Conantokin-G from Conus geographus venom
17 Amino Acids · MW: 2,150 Da
Amino Acids
17
Molecular Weight
2,150 Da
Half-life
Minutes to hours
Research Score
4.4
Studies
95
Storage
Store lyophilized at -20°C, reconstituted at 2-8°C
What is Conantokin-G?
Conantokin-G is a gamma-carboxyglutamate-rich cone snail peptide that antagonizes NMDA receptor activity. It has been used extensively to study excitatory neurotransmission and seizure biology.
Key Benefits & Mechanisms
NMDA receptor antagonism
seizure-model research
excitatory neurotransmission mapping
pain-mechanism studies
Research Summary
Research has shown conantokin-G can suppress NMDA-mediated responses in a sequence- and modification-dependent manner. It remains a classic marine peptide tool for probing glutamatergic signaling and analgesia-related pathways.
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Experimental