Conantokin-G vs Apratoxin A

Head-to-head comparison of Conantokin-G (Conantokin-G from Conus geographus venom) and Apratoxin A (Apratoxin A) — benefits, dosing, side effects, research data, and where to buy.

Research Score

PropertyConantokin-GApratoxin A
CategoryExperimentalExperimental
Full NameConantokin-G from Conus geographus venomApratoxin A
Molecular Weight2,150 DaN/A
Half-LifeMinutes to hoursN/A
Amino Acids17N/A
Typical Dose0.1-10 nmol intrathecal|10-1000 nM in vitro|single-dose rodent studiesN/A in humans; nanomolar in vitro
RouteIntrathecalIntraperitoneal / Intravenous (preclinical)
Purity≥98%≥98%
Studies Count95140
Research StatusPre-clinicalPre-clinical

Conantokin-G Benefits

  • NMDA receptor antagonism
  • seizure-model research
  • excitatory neurotransmission mapping
  • pain-mechanism studies

Apratoxin A Benefits

  • antineoplastic
  • anti-angiogenic
  • Sec61 inhibition
  • anti-proliferative

Conantokin-G Dosing

Intrathecal administration in seizure/pain models|NMDA receptor assays|In vitro excitation studies

Apratoxin A Dosing

preclinical in vitro nanomolar use|animal studies only|no human dosing established

Conantokin-G Side Effects

  • Sedation or dizziness in animals
  • motor effects at high exposure
  • off-target NMDA modulation

Apratoxin A Side Effects

  • hepatotoxicity
  • general cytotoxicity
  • GI toxicity

Research Overview

Conantokin-G

Research has shown conantokin-G can suppress NMDA-mediated responses in a sequence- and modification-dependent manner. It remains a classic marine peptide tool for probing glutamatergic signaling and analgesia-related pathways.

Apratoxin A

Apratoxin A is a well-studied lead compound for targeting secretory and membrane protein biogenesis in cancer cells. Medicinal chemistry programs around apratoxins focus on improving selectivity and reducing hepatotoxicity while preserving potency.

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Common Stacking Partners

Conantokin-G stacks with:

ketaminememantinelamotrigine

Apratoxin A stacks with:

gemcitabinedocetaxelEGFR inhibitors
cone-snailvenom-peptidenmda-antagonistneurosciencemarine-derivedcyanobacteriadepsipeptideSec61