Conantokin-G vs RgIA
Head-to-head comparison of Conantokin-G (Conantokin-G from Conus geographus venom) and RgIA (alpha-Conotoxin RgIA from Conus regius venom) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Conantokin-G | RgIA |
|---|---|---|
| Category | Experimental | Experimental |
| Full Name | Conantokin-G from Conus geographus venom | alpha-Conotoxin RgIA from Conus regius venom |
| Molecular Weight | 2,150 Da | 1,670 Da |
| Half-Life | Minutes to hours | Minutes to hours |
| Amino Acids | 17 | 13 |
| Typical Dose | 0.1-10 nmol intrathecal|10-1000 nM in vitro|single-dose rodent studies | 10-300 pmol intrathecal|1-100 nM in vitro|single-dose rodent studies |
| Route | Intrathecal | Intrathecal |
| Purity | ≥98% | ≥98% |
| Studies Count | 95 | 130 |
| Research Status | Pre-clinical | Pre-clinical |
Conantokin-G Benefits
- ✓NMDA receptor antagonism
- ✓seizure-model research
- ✓excitatory neurotransmission mapping
- ✓pain-mechanism studies
RgIA Benefits
- ✓alpha9alpha10 nAChR selectivity
- ✓neuropathic pain model tool
- ✓neuroimmune signaling research
- ✓analgesic lead discovery
Conantokin-G Dosing
Intrathecal administration in seizure/pain models|NMDA receptor assays|In vitro excitation studies
RgIA Dosing
Intrathecal bolus in rodent pain models|Patch-clamp assays on alpha9alpha10 receptors|Single-dose pre-clinical screening
Conantokin-G Side Effects
- ⚠Sedation or dizziness in animals
- ⚠motor effects at high exposure
- ⚠off-target NMDA modulation
RgIA Side Effects
- ⚠Transient autonomic effects
- ⚠off-target nicotinic blockade
- ⚠injection-site irritation
Research Overview
Conantokin-G
Research has shown conantokin-G can suppress NMDA-mediated responses in a sequence- and modification-dependent manner. It remains a classic marine peptide tool for probing glutamatergic signaling and analgesia-related pathways.
RgIA
Scientific studies show RgIA can strongly inhibit alpha9alpha10 nicotinic signaling with high selectivity compared with many other nAChR ligands. It is widely used to probe peripheral sensory pathways and inflammation-linked pain mechanisms.
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