RgIA vs Apratoxin A
Head-to-head comparison of RgIA (alpha-Conotoxin RgIA from Conus regius venom) and Apratoxin A (Apratoxin A) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | RgIA | Apratoxin A |
|---|---|---|
| Category | Experimental | Experimental |
| Full Name | alpha-Conotoxin RgIA from Conus regius venom | Apratoxin A |
| Molecular Weight | 1,670 Da | N/A |
| Half-Life | Minutes to hours | N/A |
| Amino Acids | 13 | N/A |
| Typical Dose | 10-300 pmol intrathecal|1-100 nM in vitro|single-dose rodent studies | N/A in humans; nanomolar in vitro |
| Route | Intrathecal | Intraperitoneal / Intravenous (preclinical) |
| Purity | ≥98% | ≥98% |
| Studies Count | 130 | 140 |
| Research Status | Pre-clinical | Pre-clinical |
RgIA Benefits
- ✓alpha9alpha10 nAChR selectivity
- ✓neuropathic pain model tool
- ✓neuroimmune signaling research
- ✓analgesic lead discovery
Apratoxin A Benefits
- ✓antineoplastic
- ✓anti-angiogenic
- ✓Sec61 inhibition
- ✓anti-proliferative
RgIA Dosing
Intrathecal bolus in rodent pain models|Patch-clamp assays on alpha9alpha10 receptors|Single-dose pre-clinical screening
Apratoxin A Dosing
preclinical in vitro nanomolar use|animal studies only|no human dosing established
RgIA Side Effects
- ⚠Transient autonomic effects
- ⚠off-target nicotinic blockade
- ⚠injection-site irritation
Apratoxin A Side Effects
- ⚠hepatotoxicity
- ⚠general cytotoxicity
- ⚠GI toxicity
Research Overview
RgIA
Scientific studies show RgIA can strongly inhibit alpha9alpha10 nicotinic signaling with high selectivity compared with many other nAChR ligands. It is widely used to probe peripheral sensory pathways and inflammation-linked pain mechanisms.
Apratoxin A
Apratoxin A is a well-studied lead compound for targeting secretory and membrane protein biogenesis in cancer cells. Medicinal chemistry programs around apratoxins focus on improving selectivity and reducing hepatotoxicity while preserving potency.
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