RgIA vs Conantokin-G
Head-to-head comparison of RgIA (alpha-Conotoxin RgIA from Conus regius venom) and Conantokin-G (Conantokin-G from Conus geographus venom) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | RgIA | Conantokin-G |
|---|---|---|
| Category | Experimental | Experimental |
| Full Name | alpha-Conotoxin RgIA from Conus regius venom | Conantokin-G from Conus geographus venom |
| Molecular Weight | 1,670 Da | 2,150 Da |
| Half-Life | Minutes to hours | Minutes to hours |
| Amino Acids | 13 | 17 |
| Typical Dose | 10-300 pmol intrathecal|1-100 nM in vitro|single-dose rodent studies | 0.1-10 nmol intrathecal|10-1000 nM in vitro|single-dose rodent studies |
| Route | Intrathecal | Intrathecal |
| Purity | ≥98% | ≥98% |
| Studies Count | 130 | 95 |
| Research Status | Pre-clinical | Pre-clinical |
RgIA Benefits
- ✓alpha9alpha10 nAChR selectivity
- ✓neuropathic pain model tool
- ✓neuroimmune signaling research
- ✓analgesic lead discovery
Conantokin-G Benefits
- ✓NMDA receptor antagonism
- ✓seizure-model research
- ✓excitatory neurotransmission mapping
- ✓pain-mechanism studies
RgIA Dosing
Intrathecal bolus in rodent pain models|Patch-clamp assays on alpha9alpha10 receptors|Single-dose pre-clinical screening
Conantokin-G Dosing
Intrathecal administration in seizure/pain models|NMDA receptor assays|In vitro excitation studies
RgIA Side Effects
- ⚠Transient autonomic effects
- ⚠off-target nicotinic blockade
- ⚠injection-site irritation
Conantokin-G Side Effects
- ⚠Sedation or dizziness in animals
- ⚠motor effects at high exposure
- ⚠off-target NMDA modulation
Research Overview
RgIA
Scientific studies show RgIA can strongly inhibit alpha9alpha10 nicotinic signaling with high selectivity compared with many other nAChR ligands. It is widely used to probe peripheral sensory pathways and inflammation-linked pain mechanisms.
Conantokin-G
Research has shown conantokin-G can suppress NMDA-mediated responses in a sequence- and modification-dependent manner. It remains a classic marine peptide tool for probing glutamatergic signaling and analgesia-related pathways.
Ready to buy?
Find both peptides from our verified, lab-tested vendors with purity certificates and third-party testing.