RgIA vs Huwentoxin-IV
Head-to-head comparison of RgIA (alpha-Conotoxin RgIA from Conus regius venom) and Huwentoxin-IV (Huwentoxin-IV from Selenocosmia huwena venom) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | RgIA | Huwentoxin-IV |
|---|---|---|
| Category | Experimental | Experimental |
| Full Name | alpha-Conotoxin RgIA from Conus regius venom | Huwentoxin-IV from Selenocosmia huwena venom |
| Molecular Weight | 1,670 Da | 4,000 Da |
| Half-Life | Minutes to hours | Minutes to hours |
| Amino Acids | 13 | 35 |
| Typical Dose | 10-300 pmol intrathecal|1-100 nM in vitro|single-dose rodent studies | 0.01-1 nmol intrathecal|1-100 nM in vitro|single-dose rodent studies |
| Route | Intrathecal | Intrathecal |
| Purity | ≥98% | ≥98% |
| Studies Count | 130 | 110 |
| Research Status | Pre-clinical | Pre-clinical |
RgIA Benefits
- ✓alpha9alpha10 nAChR selectivity
- ✓neuropathic pain model tool
- ✓neuroimmune signaling research
- ✓analgesic lead discovery
Huwentoxin-IV Benefits
- ✓Nav1.7 selectivity
- ✓pain-channel validation
- ✓action-potential research
- ✓analgesic lead optimization
RgIA Dosing
Intrathecal bolus in rodent pain models|Patch-clamp assays on alpha9alpha10 receptors|Single-dose pre-clinical screening
Huwentoxin-IV Dosing
In vitro Nav1.7 electrophysiology|Intrathecal rodent analgesia studies|Single-bolus channel selectivity assays
RgIA Side Effects
- ⚠Transient autonomic effects
- ⚠off-target nicotinic blockade
- ⚠injection-site irritation
Huwentoxin-IV Side Effects
- ⚠Neurological impairment at high exposure
- ⚠off-target sodium-channel effects
- ⚠injection-site irritation
Research Overview
RgIA
Scientific studies show RgIA can strongly inhibit alpha9alpha10 nicotinic signaling with high selectivity compared with many other nAChR ligands. It is widely used to probe peripheral sensory pathways and inflammation-linked pain mechanisms.
Huwentoxin-IV
Studies show huwentoxin-IV can inhibit sodium-channel currents with notable selectivity, making it useful for dissecting pain-sensing neuron excitability. It is one of the better known spider-venom templates for Nav1.7-targeted drug discovery.
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