RgIA vs Dolastatin 10
Head-to-head comparison of RgIA (alpha-Conotoxin RgIA from Conus regius venom) and Dolastatin 10 (Dolastatin 10) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | RgIA | Dolastatin 10 |
|---|---|---|
| Category | Experimental | Experimental |
| Full Name | alpha-Conotoxin RgIA from Conus regius venom | Dolastatin 10 |
| Molecular Weight | 1,670 Da | 771.0 Da |
| Half-Life | Minutes to hours | N/A |
| Amino Acids | 13 | 5 |
| Typical Dose | 10-300 pmol intrathecal|1-100 nM in vitro|single-dose rodent studies | N/A in humans; subnanomolar to low-nanomolar in vitro |
| Route | Intrathecal | Intravenous |
| Purity | ≥98% | ≥98% |
| Studies Count | 130 | 300 |
| Research Status | Pre-clinical | Pre-clinical |
RgIA Benefits
- ✓alpha9alpha10 nAChR selectivity
- ✓neuropathic pain model tool
- ✓neuroimmune signaling research
- ✓analgesic lead discovery
Dolastatin 10 Benefits
- ✓antineoplastic
- ✓microtubule disruption
- ✓antimitotic
- ✓ADC payload scaffold
RgIA Dosing
Intrathecal bolus in rodent pain models|Patch-clamp assays on alpha9alpha10 receptors|Single-dose pre-clinical screening
Dolastatin 10 Dosing
research-grade in vitro nanomolar use|early IV oncology exploration|no approved dosing regimen
RgIA Side Effects
- ⚠Transient autonomic effects
- ⚠off-target nicotinic blockade
- ⚠injection-site irritation
Dolastatin 10 Side Effects
- ⚠peripheral neuropathy
- ⚠neutropenia
- ⚠fatigue
Research Overview
RgIA
Scientific studies show RgIA can strongly inhibit alpha9alpha10 nicotinic signaling with high selectivity compared with many other nAChR ligands. It is widely used to probe peripheral sensory pathways and inflammation-linked pain mechanisms.
Dolastatin 10
Dolastatin 10 became famous for extreme cytotoxic potency and its ability to block tubulin polymerization. Although the native compound itself did not become a standard therapy, it inspired a major class of clinically important auristatin-based payloads.
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