Dolastatin 10
Dolastatin 10
5 Amino Acids · MW: 771.0 Da
Amino Acids
5
Molecular Weight
771.0 Da
Half-life
N/A
Research Score
4.7
Studies
300
Storage
Store lyophilized at -20°C, reconstituted at 2-8°C
What is Dolastatin 10?
Dolastatin 10 is a marine-derived linear pentapeptide originally isolated from Dolabella auricularia and later linked to cyanobacterial sources. It is a highly potent microtubule inhibitor and a key scaffold behind multiple auristatin payloads used in modern drug development.
Key Benefits & Mechanisms
antineoplastic
microtubule disruption
antimitotic
ADC payload scaffold
Research Summary
Dolastatin 10 became famous for extreme cytotoxic potency and its ability to block tubulin polymerization. Although the native compound itself did not become a standard therapy, it inspired a major class of clinically important auristatin-based payloads.
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Experimental