Conantokin-G vs Mambalgin-1
Head-to-head comparison of Conantokin-G (Conantokin-G from Conus geographus venom) and Mambalgin-1 (Mambalgin-1 from Dendroaspis polylepis venom) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Conantokin-G | Mambalgin-1 |
|---|---|---|
| Category | Experimental | Experimental |
| Full Name | Conantokin-G from Conus geographus venom | Mambalgin-1 from Dendroaspis polylepis venom |
| Molecular Weight | 2,150 Da | 6,300 Da |
| Half-Life | Minutes to hours | Minutes to hours |
| Amino Acids | 17 | 57 |
| Typical Dose | 0.1-10 nmol intrathecal|10-1000 nM in vitro|single-dose rodent studies | 0.1-1 nmol intrathecal|10-100 nM in vitro|single-dose rodent studies |
| Route | Intrathecal | Intrathecal |
| Purity | ≥98% | ≥98% |
| Studies Count | 95 | 55 |
| Research Status | Pre-clinical | Pre-clinical |
Conantokin-G Benefits
- ✓NMDA receptor antagonism
- ✓seizure-model research
- ✓excitatory neurotransmission mapping
- ✓pain-mechanism studies
Mambalgin-1 Benefits
- ✓ASIC channel inhibition
- ✓non-opioid analgesia research
- ✓sensory-neuron physiology
- ✓lead optimization for pain therapeutics
Conantokin-G Dosing
Intrathecal administration in seizure/pain models|NMDA receptor assays|In vitro excitation studies
Mambalgin-1 Dosing
Intrathecal pain-behavior studies|ASIC1a/ASIC1b electrophysiology|Acute dosing in rodents
Conantokin-G Side Effects
- ⚠Sedation or dizziness in animals
- ⚠motor effects at high exposure
- ⚠off-target NMDA modulation
Mambalgin-1 Side Effects
- ⚠Hypoactivity at high dose
- ⚠off-target ASIC blockade
- ⚠local irritation
Research Overview
Conantokin-G
Research has shown conantokin-G can suppress NMDA-mediated responses in a sequence- and modification-dependent manner. It remains a classic marine peptide tool for probing glutamatergic signaling and analgesia-related pathways.
Mambalgin-1
Pre-clinical work shows mambalgin-1 can reduce pain behaviors by modulating proton-gated ion channels in peripheral and central pathways. It has become an important template for developing ASIC-targeted analgesics.
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