Kahalalide F vs Didemnin B

Head-to-head comparison of Kahalalide F (Kahalalide F) and Didemnin B (Didemnin B) — benefits, dosing, side effects, research data, and where to buy.

Research Score

PropertyKahalalide FDidemnin B
CategoryExperimentalExperimental
Full NameKahalalide FDidemnin B
Molecular Weight1111.3 Da1112.4 Da
Half-LifeN/AN/A
Amino AcidsN/AN/A
Typical Dose0.1-3 mg/m2 IV in early trials0.05-2 mg/m2 IV in early trials
RouteIntravenousIntravenous
Purity≥98%≥98%
Studies Count85120
Research StatusPre-clinicalClinical

Kahalalide F Benefits

  • antineoplastic
  • pro-apoptotic
  • membrane-active
  • anti-proliferative

Didemnin B Benefits

  • antineoplastic
  • antiviral
  • pro-apoptotic
  • immunomodulatory

Kahalalide F Dosing

IV infusion in phase I oncology studies|dose escalation used in trials|preclinical nanomolar assays

Didemnin B Dosing

historic IV phase I/II oncology regimens|dose escalation in early trials|no approved dosing regimen

Kahalalide F Side Effects

  • fatigue
  • nausea
  • transaminase elevation

Didemnin B Side Effects

  • nausea
  • vomiting
  • myelosuppression

Research Overview

Kahalalide F

Kahalalide F was investigated in multiple preclinical and early clinical cancer studies because of its unusual membrane-disrupting and anti-tumor effects. Development highlighted the promise and limits of marine depsipeptides as oncology leads.

Didemnin B

Didemnin B showed strong cytotoxic and antiviral activity in early literature and became an important scaffold for later marine drug development. Its clinical progress was limited by toxicity, but it remains highly cited as a foundational marine depsipeptide.

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Common Stacking Partners

Kahalalide F stacks with:

paclitaxelcisplatincarboplatin

Didemnin B stacks with:

cisplatindoxorubicingemcitabine
marine-derivedsea-slugdepsipeptideoncologytunicateantitumor