TFF3 vs Met-enkephalin
Head-to-head comparison of TFF3 (Trefoil Factor 3 (intestinal trefoil factor)) and Met-enkephalin (Tyr-Gly-Gly-Phe-Met) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | TFF3 | Met-enkephalin |
|---|---|---|
| Category | Gastrointestinal | Pain Management |
| Full Name | Trefoil Factor 3 (intestinal trefoil factor) | Tyr-Gly-Gly-Phe-Met |
| Molecular Weight | 6370 Da | 573.67 Da |
| Half-Life | unknown; likely short in circulation | 1-5 minutes in plasma |
| Amino Acids | 59 | 5 |
| Typical Dose | research-only; model-dependent microgram to milligram ranges | 0.1-5 ug per animal |
| Route | Oral/Intrarectal | Intrathecal / intracerebroventricular |
| Purity | ≥98% | ≥98% |
| Studies Count | 70 | 1200 |
| Research Status | Pre-clinical | Pre-clinical |
TFF3 Benefits
- ✓epithelial-restitution
- ✓mucus-support
- ✓wound-healing
- ✓barrier-stability
Met-enkephalin Benefits
- ✓endogenous opioid signaling
- ✓analgesic reference ligand
- ✓spinal antinociception
- ✓neurochemical pain-pathway probe
TFF3 Dosing
preclinical dosing varies widely by model|local or systemic administration|repeated dosing for inflammatory injury studies
Met-enkephalin Dosing
Intrathecal 0.1-5 ug per animal|Intracerebroventricular 0.1-2 ug per animal|In vitro 1-100 nM
TFF3 Side Effects
- ⚠limited human dosing data
- ⚠protein stability issues
- ⚠potential immunogenicity with exogenous use
Met-enkephalin Side Effects
- ⚠sedation at higher exposure
- ⚠constipation-like opioid effects
- ⚠rapid enzymatic degradation
Research Overview
TFF3
TFF3 is a well-established mucosal repair factor in the literature, especially in the context of intestinal injury and inflammation. Experimental studies support a role in accelerating restitution and protecting the epithelial surface in gut disease models.
Met-enkephalin
Met-enkephalin has been extensively used in receptor pharmacology and nociception studies to map mu and delta opioid biology. The main limitation in translational work is very short half-life from peptidase cleavage and poor systemic stability.
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