Met-enkephalin vs Teduglutide
Head-to-head comparison of Met-enkephalin (Tyr-Gly-Gly-Phe-Met) and Teduglutide (Teduglutide (glycyl-2 human glucagon-like peptide-2 analog)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Met-enkephalin | Teduglutide |
|---|---|---|
| Category | Pain Management | Gastrointestinal |
| Full Name | Tyr-Gly-Gly-Phe-Met | Teduglutide (glycyl-2 human glucagon-like peptide-2 analog) |
| Molecular Weight | 573.67 Da | 3752 Da |
| Half-Life | 1-5 minutes in plasma | approximately 2-3 hours |
| Amino Acids | 5 | 33 |
| Typical Dose | 0.1-5 ug per animal | 0.05 mg/kg/day |
| Route | Intrathecal / intracerebroventricular | Subcutaneous |
| Purity | ≥98% | ≥98% |
| Studies Count | 1200 | 300 |
| Research Status | Pre-clinical | Clinical |
Met-enkephalin Benefits
- ✓endogenous opioid signaling
- ✓analgesic reference ligand
- ✓spinal antinociception
- ✓neurochemical pain-pathway probe
Teduglutide Benefits
- ✓mucosal-growth
- ✓absorption-support
- ✓barrier-repair
- ✓intestinal-adaptation
Met-enkephalin Dosing
Intrathecal 0.1-5 ug per animal|Intracerebroventricular 0.1-2 ug per animal|In vitro 1-100 nM
Teduglutide Dosing
0.05 mg/kg once daily subcutaneous injection|chronic maintenance dosing in approved use|monitor fluid status and intestinal anatomy
Met-enkephalin Side Effects
- ⚠sedation at higher exposure
- ⚠constipation-like opioid effects
- ⚠rapid enzymatic degradation
Teduglutide Side Effects
- ⚠abdominal pain
- ⚠fluid retention
- ⚠polyp/neoplasia monitoring needed
Research Overview
Met-enkephalin
Met-enkephalin has been extensively used in receptor pharmacology and nociception studies to map mu and delta opioid biology. The main limitation in translational work is very short half-life from peptidase cleavage and poor systemic stability.
Teduglutide
Teduglutide has robust clinical evidence showing improved intestinal absorption and reduced parenteral nutrition dependence in short bowel syndrome. Its mechanism, via GLP-2 receptor activation, makes it highly relevant to mucosal healing and intestinal adaptation research.
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