Met-enkephalin vs DPDPE
Head-to-head comparison of Met-enkephalin (Tyr-Gly-Gly-Phe-Met) and DPDPE ([D-Pen2, D-Pen5]-enkephalin) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Met-enkephalin | DPDPE |
|---|---|---|
| Category | Pain Management | Pain Management |
| Full Name | Tyr-Gly-Gly-Phe-Met | [D-Pen2, D-Pen5]-enkephalin |
| Molecular Weight | 573.67 Da | 645.79 Da |
| Half-Life | 1-5 minutes in plasma | 15-60 minutes in plasma |
| Amino Acids | 5 | 5 |
| Typical Dose | 0.1-5 ug per animal | 0.01-1 ug per animal |
| Route | Intrathecal / intracerebroventricular | Intrathecal / intracerebroventricular |
| Purity | ≥98% | ≥98% |
| Studies Count | 1200 | 800 |
| Research Status | Pre-clinical | Pre-clinical |
Met-enkephalin Benefits
- ✓endogenous opioid signaling
- ✓analgesic reference ligand
- ✓spinal antinociception
- ✓neurochemical pain-pathway probe
DPDPE Benefits
- ✓delta-opioid selectivity
- ✓improved conformational stability
- ✓analgesic receptor mapping
- ✓useful in chronic pain models
Met-enkephalin Dosing
Intrathecal 0.1-5 ug per animal|Intracerebroventricular 0.1-2 ug per animal|In vitro 1-100 nM
DPDPE Dosing
Intrathecal 0.01-1 ug per animal|Intracerebroventricular 0.01-0.5 ug per animal|In vitro 0.1-20 nM
Met-enkephalin Side Effects
- ⚠sedation at higher exposure
- ⚠constipation-like opioid effects
- ⚠rapid enzymatic degradation
DPDPE Side Effects
- ⚠sedation
- ⚠nausea-like opioid effects
- ⚠tolerance with repeated dosing
Research Overview
Met-enkephalin
Met-enkephalin has been extensively used in receptor pharmacology and nociception studies to map mu and delta opioid biology. The main limitation in translational work is very short half-life from peptidase cleavage and poor systemic stability.
DPDPE
DPDPE is widely cited in opioid pharmacology because it helped establish the functional role of delta-opioid receptors in pain control. Its constrained structure is also used to explore how peptide cyclization changes potency, stability, and tissue selectivity.
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